Dubai: A study led by the Cleveland Clinic has revealed a troubling association between a higher amount of sugar substitute xylitol and an increased risk of cardiovascular diseases. The research, spearheaded by Dr. Stanley Hazen, confirmed this link through a comprehensive analysis involving patient data, preclinical models, and a clinical intervention study. The findings were published in the European Heart Journal.
Common uses and rising popularity
Xylitol, widely used in sugar-free confectionery, gums, baked goods, and oral products like toothpaste, has become a popular sugar substitute over the past decade. Its zero-calorie appeal has made it a staple in processed foods marketed as healthy alternatives. However, this new study raises significant concerns about its safety.
Detailed findings and immediate concerns
The research team discovered that high levels of circulating xylitol were associated with a higher three-year risk of cardiovascular events in an analysis of over 3,000 patients in the U.S. and Europe. Patients with the highest xylitol levels in their plasma were significantly more likely to experience cardiovascular events.
Preclinical testing confirmed that xylitol promotes platelet clotting and increases thrombosis risk. Additionally, ingesting a xylitol-sweetened drink led to a marked increase in clotting activity compared to a glucose-sweetened drink.
Call for further investigation
“This study underscores the urgent need for more research into sugar alcohols and artificial sweeteners, especially given their widespread use in combating obesity and diabetes,” said Dr. Hazen.
He cautioned against panic but advised awareness regarding high consumption of xylitol-rich products. Further studies are needed to assess the long-term cardiovascular safety of xylitol, as the current research only demonstrates an association, not causation.
Broader context and ongoing research
This study is part of Dr. Hazen’s extensive investigation into factors contributing to cardiovascular risk. His team focuses on identifying chemical signatures in blood that can predict heart and metabolic disease development. Dr. Hazen, a pioneer in atherosclerosis and inflammatory disease research, has previously linked erythritol to cardiovascular risk and made significant discoveries in gut microbial pathways related to cardiovascular and metabolic diseases.
Practical advice for consumers
While the findings highlight potential risks, Dr. Hazen advises consulting healthcare professionals for personalized dietary recommendations. Awareness and moderation are key, particularly for those using xylitol-containing products frequently.
As the popularity of sugar substitutes like xylitol continues to rise, this study from Cleveland Clinic highlights the critical need for further investigation into their long-term health impacts. Consumers are encouraged to stay informed and seek professional advice to make healthier food choices.